In 1981, Daddy-O began his career as the lead member of the band Stetsasonic, which included Prince Paul, in Brooklyn, New York. He produced and remixed songs for musical acts such as Mary J. Blige, Queen Latifah, Red Hot Chili Peppers, The B-52's, Jeffrey Osborne, Chante Moore, and Lil' Kim.

From 1994 to 1998, he was a Senior Director for MCA Records. After leaving MCA, he worked for Motown Records and various other entertainment agencies, where he helped to produce and discover talent. Other acts with which he has been associated include Sonic Youth, Sublime, Barry White, They Might Be Giants, Camron, Pizzicato 5, and Third World.

In 2005, Daddy-O began as Creative Director for AND1 Basketball Company, heavily involved in the Mixtape Vol. 1-4. He was given the title of Creative Director for Bitrebels.com in 2013. 2014 found Daddy-O in an executive position at PLAT4M LLC, a management consulting firm. In 2015, Daddy-O joined the CloudSpray team as a management and marketing consultant. In 2016, Daddy-O and his partner Lion Lindwedel (founder of True School Entertainment) formed their co-owned label, Odad Truth Records. He released his solo albums on the OTR Label with digital distribution on Chuck D's distribution company SpitDigital. The first release was #EverybodyButKRS, followed in February 2016 with The Odad, the Gun, & the Children, El Dolor De Las Calles, No Tablecloths in 2018, From My Hood 2 U in 2019, and the most recent solo release of G.O.A.T. Antidote in 2020.

2021 saw the resurgence of Stetsasonic, their first single in many years, "(Now Y'all Giving Up) Love", and the forthcoming album, "Here We Go Again". Professor Daddy-O is continuing to add to his catalog with a couple of upcoming albums with some very familiar faces.